Mesangial cells possess an asialoglycoprotein receptor with affinity for human immunoglobulin A.
نویسندگان
چکیده
منابع مشابه
Absence of CD89, polymeric immunoglobulin receptor, and asialoglycoprotein receptor on human mesangial cells.
IgA nephropathy (IgAN) is characterized by raised serum IgA and predominant mesangial IgA deposits of polymeric nature. The expression of IgA receptor molecules in white blood cells and glomerular mesangial cells has recently attracted much attention in relation to the uptake of IgA by these cells. This study investigates the expression of IgA Fc receptor (Fc alphaR1 or CD89), asialoglycoprotei...
متن کاملTwo asialoglycoprotein receptor polypeptides in human hepatoma cells.
Two cDNA clones isolated from a HepG2 lambda gt11 library encode the classical asialoglycoprotein receptor, H1, as well as a homologous membrane glycoprotein, H2 (Spiess, M., and Lodish, H.F. (1985) Proc. Natl. Acad. Sci. U.S.A. 82, 6465-6469). To study the relationship of H2 to H1 and its possible role in receptor-mediated endocytosis of desialyated glycoproteins, we generated anti-peptide ant...
متن کاملHuman Epidermal Langerhans Cells Express the High Affinity Receptor for Immunoglobulin E
From the *Laboratory of lmmunodermatology, Department of Dermatology, University of Munich Medical School, 8000 Munich 2, Germany; the ~Laboratoire d'Histocompatibilitd and Institut National de Ia Santd et de la Recherche M~dicale U.311, Centre R~gional de ~ansfusion Sanguine, 67000 Strasbour,~ France; SHoffman-La Roche Ina, Nude),, New Jersey 07110-1199; and the IIDepartment of Dermatology, Un...
متن کاملHuman epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI)
It has been suggested that epidermal Langerhans cells (LC) bearing immunoglobulin E (IgE) may be involved in the genesis of atopic disease. The identity of the IgE receptor(s) on LC remained unclear, although it represents a crucial point in understanding cellular events linked to the binding of allergens to LC via IgE. In this report, we demonstrate that epidermal LC express the high affinity ...
متن کاملImmature human dendritic cells express asialoglycoprotein receptor isoforms for efficient receptor-mediated endocytosis.
In a search for genes expressed by dendritic cells (DC), we have cloned cDNAs encoding different forms of an asialoglycoprotein receptor (ASGPR). The DC-ASGPR represents long and short isoforms of human macrophage lectin, a Ca(2+)-dependent type II transmembrane lectin displaying considerable homology with the H1 and H2 subunits of the hepatic ASGPR. Immunoprecipitation from DC using an anti-DC...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 1998
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.v94568